Wednesday 5 March 2014

3D Structure of Protein

     "Science is more than the body of knowledge, its a way of thinking, a way of skeptically interrogating the universe" -Carl Sagan

3D protein structure
The three dimensional structure of a protein is determined by its sequence, and the function of a protein is determined by its three dimensional structure. 

Four levels of structure. 
  • Primary - Amino acids sequence, are covalently link (Peptide bonds) and any disulphide bridge are included in the primary structure. The following protein structures are dependent upon non covalent interactions.
  • Secondary - Regular reoccurring arrangement that occurs within adjacent amino acids. Which are:
        • Alpha helix
        • Beta pleated sheet 
  • Tertiary - Spatial relationship between all peptides in a protein. Protein folding brings sequentially distance close together. Fibrous, long strands or sheets, structural proteins with a single secondary type of secondary structure.Globular, spherical; complex structures with many types of secondary structure. Enzymes and olypeptide hormones are usually globular peptides.   
  • Quaternary - Arrangement of polypeptide change ( sub units ) within a protein. 
Protein Structure :)

No comments:

Post a Comment